GAS-CHROMATOGRAPHIC DETERMINATION OF ZOPICLONE IN PLASMA AFTER SOLID-PHASE EXTRACTION

被引：17

作者：

GAILLARD, Y

GAYMONTCHAMP, JP

OLLAGNIER, M

机构：

[1] Laboratoire Central de Pharmacologie et Toxicologie, Hôpital de Bellevue, 42023 Saint-Etienne Cedex, Boulevard Pasteur

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 619卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80122-K

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A gas chromatographic technique for determining zopiclone based on a solid-phase extraction procedure with C18 cartridge for sample clean-up is presented. Quantification can be achieved with 1 ml of plasma. The method uses prazepam as internal standard. Zopiclone is separated on a 5% phenyl methyl silicone analytical column and detected with an electron-capture detector, which consequently allows a limit of quantitation of 2 mug/l. It is thus simple, rapid, sensitive and linear over the range 5-2000 mug/l.

引用

页码：310 / 314

页数：5

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