ABSENCE OF HEPATIC CYTOCHROME P450BUFI CAUSES GENETICALLY DEFICIENT DEBRISOQUINE OXIDATION IN MAN

被引：179

作者：

ZANGER, UM

VILBOIS, F

HARDWICK, JP

MEYER, UA

机构：

[1] UNIV BASEL,BIOCTR,DEPT PHARMACOL,CH-4056 BASEL,SWITZERLAND

[2] ARGONNE NATL LAB,DIV BIOMED,ARGONNE,IL 60439

来源：

BIOCHEMISTRY | 1988年 / 27卷 / 15期

关键词：

D O I：

10.1021/bi00415a010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5447 / 5454

页数：8

共 36 条

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[2] GENETIC-POLYMORPHISM IN DRUG OXIDATION - INVITRO STUDIES OF HUMAN DEBRISOQUINE 4-HYDROXYLASE AND BUFURALOL 1'-HYDROXYLASE ACTIVITIES
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[3] DIFFERENCES IN THE MECHANISM OF NADPH-SUPPORTED AND CUMENE HYDROPEROXIDE-SUPPORTED REACTIONS OF CYTOCHROME-P-450
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[4] EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER
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[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) : 89 - 91
[5] CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS
DAYER, P
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MEYER, UA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) : 374 - 380
[6] ENZYMATIC BASIS OF THE DEBRISOQUINE SPARTEINE-TYPE GENETIC-POLYMORPHISM OF DRUG OXIDATION - CHARACTERIZATION OF BUFURALOL 1'-HYDROXYLATION IN LIVER-MICROSOMES OF INVIVO PHENOTYPED CARRIERS OF THE GENETIC DEFICIENCY
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EICHELBAUM, M
MEYER, UA
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (23) : 4145 - 4152
[7] de Montellano P. R. Oritz, 1986, CYTOCHROME P 450 STR, P1
[8] DISTLERATH LM, 1985, J BIOL CHEM, V260, P9057
[9] CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 INVOLVED IN THE OXIDATION OF DEBRISOQUINE AND OTHER DRUGS BY USING ANTIBODIES RAISED TO THE ANALOGOUS RAT ENZYME
DISTLERATH, LM
GUENGERICH, FP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23): : 7348 - 7352
[10] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT
EICHELBAUM, M
SPANNBRUCKER, N
STEINCKE, B
DENGLER, HJ
[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) : 183 - 187

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