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1-(3-CYANO-2,3-DIDEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)THYMINE (CYANOTHYMIDINE) - SYNTHESIS AND ANTIVIRAL EVALUATION AGAINST HUMAN IMMUNODEFICIENCY VIRUS

被引：26
作者：
GREENGRASS, CW
HOOPLE, DWT
STREET, SDA
HAMILTON, F
MARRIOTT, MS
BORDNER, J
DALGLEISH, AG
MITSUYA, H
BRODER, S
机构：
[1] PFIZER INC,CENT RES LABS,GROTON,CT 06340
[2] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND
[3] NCI,BETHESDA,MD 20892
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 03期
关键词：
D O I：
10.1021/jm00123a019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：618 / 622
页数：5
相关论文
共 32 条
  • [1] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO
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    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) : 128 - 134
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    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 151 (01) : 608 - 614
  • [5] STRUCTURE AND CONFORMATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT), AN INHIBITOR OF THE HIV (AIDS) VIRUS
    BIRNBAUM, GI
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    [J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1987, 65 (09): : 2135 - 2139
  • [6] BRODER S, 1987, NEW SCI 0723, P22
  • [7] 3'-C-CYANO-3'-DEOXYTHYMIDINE
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    [J]. TETRAHEDRON LETTERS, 1988, 29 (08) : 941 - 944
  • [8] AZIDOTHYMIDINE - CRYSTAL-STRUCTURE AND POSSIBLE FUNCTIONAL-ROLE OF THE AZIDO GROUP
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    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) : 8239 - 8242
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