DISSECTION OF THE STRUCTURE AND ACTIVITY OF THE TYROSYL-TRANSFER RNA-SYNTHETASE BY SITE-DIRECTED MUTAGENESIS

被引：246

作者：

FERSHT, AR

机构：

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 25期

关键词：

D O I：

10.1021/bi00399a001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：8031 / 8037

页数：7

共 50 条

[11]

Fersht A, 1985, ENZYME STRUCTURE MEC

[12]

Fersht A. R., 1977, ENZYME STRUCTURE MEC

[13] DEMONSTRATION OF 2 ACTIVE-SITES ON A MONOMERIC AMINOACYL-TRANSFER-RNA SYNTHETASE - POSSIBLE ROLES OF NEGATIVE COOPERATIVITY AND HALF-OF-SITES REACTIVITY IN OLIGOMERIC ENZYMES [J].

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[14] FINE-STRUCTURE ACTIVITY ANALYSIS OF MUTATIONS AT POSITION 51 OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].

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WILKINSON, AJ ;

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[15] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].

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[16] THE HYDROGEN-BOND IN MOLECULAR RECOGNITION [J].

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[17] LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE [J].

FERSHT, AR ;

MULVEY, RS ;

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[18] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS [J].

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LEATHERBARROW, RJ ;

WELLS, TNC .

BIOCHEMISTRY, 1987, 26 (19) :6030-6038

[19] QUANTITATIVE-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS BY LINEAR FREE-ENERGY RELATIONSHIPS [J].

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LEATHERBARROW, RJ ;

WELLS, TNC .

NATURE, 1986, 322 (6076) :284-286

[20] BINDING-ENERGY AND CATALYSIS - A LESSON FROM PROTEIN ENGINEERING OF THE TYROSYL-TRANSFER RNA-SYNTHETASE [J].

FERSHT, AR ;

LEATHERBARROW, RJ ;

WELLS, TNC .

TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (08) :321-325

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