STUDIES ON RUBIA AKANE (RA) DERIVATIVES .7. THIOAMIDE ANALOGS OF RAS - ANTITUMOR CYCLIC HEXAPEPTIDES

被引：20

作者：

HITOTSUYANAGI, Y ^{[1
]}

SUZUKI, J ^{[1
]}

MATSUMOTO, Y ^{[1
]}

TAKEYA, K ^{[1
]}

ITOKAWA, H ^{[1
]}

机构：

[1] TOKYO COLL PHARM,DEPT PHARMACOGNOSY,HACHIOJI,TOKYO 19203,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 14期

关键词：

D O I：

10.1039/p19940001887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Tyr-3-psi(CS-NH)-Ala-4]RA-VII 3, [Tyr-3-psi(CS-NH)-Ala-4; Tyr-6-psi(CS-NH)-D-Ala-1]RA-VII 4, [Tyr-3-psi(CS-NH)-Ala-4]RA-V 7 and [Tyr-3-psi(CS-NH)-Ala-4]RA-X methyl ester 8 have been prepared from corresponding RAs, and they showed more promising in vitro antitumour activity than the parent compounds.

引用

页码：1887 / 1889

页数：3

共 19 条

[1] A THIOAMIDE SUBSTRATE OF CARBOXYPEPTIDASE-A
BARTLETT, PA
SPEAR, KL
JACOBSEN, NE
[J]. BIOCHEMISTRY, 1982, 21 (07) : 1608 - 1611
[2] RECEPTOR LIGANDS WHICH BIND THE OXYTOCIN RECEPTOR WITH SELECTIVITY AND HIGH-AFFINITY - CHEMICAL MODIFICATION OF A STREPTOMYCES-SILVENSIS DERIVED CYCLIC HEXAPEPTIDE
BOCK, MG
DIPARDO, RM
WILLIAMS, PD
PETTIBONE, DJ
CLINESCHMIDT, BV
BALL, RG
VEBER, DF
FREIDINGER, RM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) : 2321 - 2323
[3] SYNTHESIS OF N29-DESMETHYL RA-VII - IDENTIFICATION OF THE PHARMACOPHORE OF RA-I-VII AND DEOXYBOUVARDIN AND REASSIGNMENT OF THE SUBUNIT FUNCTIONAL ROLES
BOGER, DL
YOHANNES, D
MYERS, JB
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (05) : 1319 - 1321
[4] CARBOXYPEPTIDASE-A CATALYZED-HYDROLYSIS OF THIOPEPTIDE AND THIONESTER ANALOGS OF SPECIFIC SUBSTRATES - AN EFFECT ON KCAT FOR PEPTIDE, BUT NOT ESTER, SUBSTRATES
CAMPBELL, P
NASHED, NT
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (19) : 5221 - 5226
[5] EVIDENCE OF A PEPTIDE BACKBONE CONTRIBUTION TOWARD SELECTIVE RECEPTOR RECOGNITION FOR LEUCINE ENKEPHALIN THIOAMIDE ANALOGS
CLAUSEN, K
SPATOLA, AF
LEMIEUX, C
SCHILLER, PW
LAWESSON, SO
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (01) : 305 - 310
[6] PREPARATION OF [D-CYSTEINE]8-CYCLOSPORINE VIA INTRAMOLECULAR SULFUR TRANSFER-REACTION
EBERLE, MK
NUNINGER, F
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (03) : 673 - 677
[7] AN IMPROVED METHOD FOR THE PREPARATION OF DESOXOPEPTIDES - REDUCTIONS OF ENDOTHIOPEPTIDES
GUZIEC, FS
WASMUND, LM
[J]. TETRAHEDRON LETTERS, 1990, 31 (01) : 23 - 26
[8] RA-III LACTONE, A 19-MEMBERED RING ANALOG OF RAS, ANTITUMOR CYCLIC HEXAPEPTIDE
HITOTSUYANAGI, Y
KONDO, K
TAKEYA, K
ITOKAWA, H
[J]. TETRAHEDRON LETTERS, 1994, 35 (14) : 2191 - 2194
[9] ITOKAWA H, 1993, CHEM PHARM BULL, V41, P1402
[10] NEW ANTITUMOR BICYCLIC HEXAPEPTIDES, RA-IX AND RA-X FROM RUBIA-CORDIFOLIA .3. CONFORMATION ANTITUMOR-ACTIVITY RELATIONSHIP
ITOKAWA, H
YAMAMIYA, T
MORITA, H
TAKEYA, K
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (04): : 455 - 459

← 1 2 →