Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

被引：128

作者：

He, Yu-Tao ^{[1
]}

Li, Lian-Hua ^{[1
]}

Yang, Yan-Fang ^{[1
]}

Zhou, Zhao-Zhao ^{[1
]}

Hua, Hui-Liang ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

Liang, Yong-Min ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 01期

关键词：

ARYL BORONIC ACIDS; BOND-FORMATION; OXIDATIVE TRIFLUOROMETHYLATION; TERMINAL ALKYNES; REDUCTIVE ELIMINATION; FLUORINE; EFFICIENT; OXYTRIFLUOROMETHYLATION; HYDROXYTRIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION;

D O I：

10.1021/ol403263c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF3-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry.

引用

页码：270 / 273

页数：4

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