Stereocontrolled synthesis of hydroxymethylene phosphonate analogues of phosphorylated tyrosine and their conversion to monofluoromethylene phosphonate analogues

被引：46

作者：

Yokomatsu, T

Yamagishi, T

Matsumoto, K

Shibuya, S

机构：

[1] TOKYO UNIV PHARM & LIFE SCI, SCH PHARM, HACHIOJI, TOKYO 19203, JAPAN

[2] TAISHO PHARMACEUT CO LTD, RES CTR, OMIYA, SAITAMA 330, JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 36期

关键词：

D O I：

10.1016/0040-4020(96)00671-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled synthesis of protected variants 13 and 15 of HPmp 2, a mimic of phosphorylated tyrosine, was achieved through either chiral-auxiliary assisted or chiral heterobimetal catalyzed stereoselective hydrophosphonylation of 4-formyl-L-phenylalanine derivative 7. Fluorination of HPmp, derivatives 13 and 15 thus obtained was carried out to give FPmp derivatives 16 and 17. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：11725 / 11738

页数：14

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