Protein-Polymer Hybrid Nanoparticles for Drug Delivery

被引：80

作者：

Ge, Jun ^{[1
,3
]}

Neofytou, Evgenios ^{[2
]}

Lei, Jiandu ^{[1
,4
]}

Beygui, Ramin E. ^{[2
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Cardiothorac Surg, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

[3] Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China

[4] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

来源：

SMALL | 2012年 / 8卷 / 23期

基金：

美国国家科学基金会;

关键词：

nanoparticles; protein-polymer conjugates; albumin; poly(methyl methacrylate); drug delivery; CORE-SHELL NANOPARTICLES; POLY(METHYL METHACRYLATE); TARGETED NANOPARTICLES; INTRACELLULAR UPTAKE; OXIDE NANOPARTICLES; RAFT POLYMERIZATION; CELLULAR UPTAKE; IN-VITRO; RELEASE; CAMPTOTHECIN;

D O I：

10.1002/smll.201200889

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amphiphilic bovine serum albumin-poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self-assembling. Loaded with the hydrophobic anti-tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3573 / 3578

页数：6

共 54 条

[1] Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines [J].

Akhlaghi, Seyedeh Parinaz ;

Saremi, Shahrooz ;

Ostad, Seyed Nasser ;

Dinarvand, Rassoul ;

Atyabi, Fatemeh .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2010, 6 (05) :689-697

[2] Covalently incorporated protein-nanogels using AGET ATRP in an inverse miniemulsion [J].

Averick, Saadyah E. ;

Magenau, Andrew J. D. ;

Simakova, Antonina ;

Woodman, Bradley F. ;

Seong, Andrew ;

Mehl, Ryan A. ;

Matyjaszewski, Krzysztof .

POLYMER CHEMISTRY, 2011, 2 (07) :1476-1478

[3] Poly(methyl methacrylate) particulate carriers in drug delivery [J].

Bettencourt, Ana ;

Almeida, Antonio J. .

JOURNAL OF MICROENCAPSULATION, 2012, 29 (04) :353-367

[4] Well-defined protein-polymer conjugates via in situ RAFT polymerization [J].

Boyer, Cyrille ;

Bulmus, Volga ;

Liu, Jingquan ;

Davis, Thomas P. ;

Stenzel, Martina H. ;

Barner-Kowollik, Christopher .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (22) :7145-7154

[5]

Chakravarty P, 2010, NAT NANOTECHNOL, V5, P607, DOI [10.1038/nnano.2010.126, 10.1038/NNANO.2010.126]

[6] Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target [J].

Cheng, Chen ;

Wei, Hua ;

Zhu, Jing-Ling ;

Chang, Cong ;

Cheng, Han ;

Li, Cao ;

Cheng, Si-Xue ;

Zhang, Xian-Zheng ;

Zhuo, Ren-Xi .

BIOCONJUGATE CHEMISTRY, 2008, 19 (06) :1194-1201

[7] Antitumor activity of β-cyclodextrin polymer -: Camptothecin conjugates [J].

Cheng, Jianjun ;

Khin, Kay T. ;

Davis, Mark E. .

MOLECULAR PHARMACEUTICS, 2004, 1 (03) :183-193

[8] Understanding the Role of Surface Charges in Cellular Adsorption versus Internalization by Selectively Removing Gold Nanoparticles on the Cell Surface with a I2/KI Etchant [J].

Cho, Eun Chul ;

Xie, Jingwei ;

Wurm, Patricia A. ;

Xia, Younan .

NANO LETTERS, 2009, 9 (03) :1080-1084

[9] A Temperature-Sensitive Drug Release System Based on Phase-Change Materials [J].

Choi, Sung-Wook ;

Zhang, Yu ;

Xia, Younan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (43) :7904-7908

[10] Temperature-regulated activity of responsive polymer-protein conjugates prepared by grafting-from via RAFT polymerization [J].

De, Priyadarsi ;

Li, Ming ;

Gondi, Sudershan R. ;

Sumerlin, Brent S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (34) :11288-+

← 1 2 3 4 5 6 →