Protein-Polymer Hybrid Nanoparticles for Drug Delivery

被引：80

作者：

Ge, Jun ^{[1
,3
]}

Neofytou, Evgenios ^{[2
]}

Lei, Jiandu ^{[1
,4
]}

Beygui, Ramin E. ^{[2
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Cardiothorac Surg, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

[3] Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China

[4] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

来源：

SMALL | 2012年 / 8卷 / 23期

基金：

美国国家科学基金会;

关键词：

nanoparticles; protein-polymer conjugates; albumin; poly(methyl methacrylate); drug delivery; CORE-SHELL NANOPARTICLES; POLY(METHYL METHACRYLATE); TARGETED NANOPARTICLES; INTRACELLULAR UPTAKE; OXIDE NANOPARTICLES; RAFT POLYMERIZATION; CELLULAR UPTAKE; IN-VITRO; RELEASE; CAMPTOTHECIN;

D O I：

10.1002/smll.201200889

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amphiphilic bovine serum albumin-poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self-assembling. Loaded with the hydrophobic anti-tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3573 / 3578

页数：6

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