A Lipase-Responsive Vehicle Using Amphipathic Polymer Synthesized with the Lipase as Catalyst

被引：35

作者：

Ge, Jun ^{[1
]}

Lu, Diannan ^{[1
]}

Yang, Cheng ^{[1
]}

Liu, Zheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2011年 / 32卷 / 06期

基金：

中国国家自然科学基金;

关键词：

biomaterials; enzymes; nanoparticles; stimuli-sensitive polymers; CANDIDA-RUGOSA LIPASE; MESOPOROUS SILICA; BLOCK-COPOLYMERS; ORGANIC-SOLVENTS; ENZYME-ACTIVITY; RELEASE; NANOPARTICLES; SYSTEM; TEMPERATURE; SURFACTANTS;

D O I：

10.1002/marc.201000746

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We describe an enzyme-responsive polymeric vehicle, which is of great interest in controlled drug delivery, biosensing, and other related areas. The polymer synthesized using lipase as catalyst in DMSO has a favorable molecular structure that is quickly hydrolyzed by lipase in aqueous phase, and allows a fast release of encapsulated molecules.

引用

页码：546 / 550

页数：5

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