Simple protocol for NMR analysis of the enantiomeric purity of diols

被引：75

作者：

Kelly, AM ^{[1
]}

Pérez-Fuertes, Y ^{[1
]}

Arimori, S ^{[1
]}

Bull, SD ^{[1
]}

James, TD ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol0602351

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral 1,2-, 1,3-, and 1,4-diols by H-1 NMR spectroscopic analysis is described. The method involves treatment with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine to afford a mixture of diastereolsomeric iminoboronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diol.

引用

收藏

页码：1971 / 1974

页数：4

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