Synthetic Glycopolypeptides as Biomimetic Analogues of Natural Glycoproteins

被引：97

作者：

Bonduelle, Colin ^{[1
]}

Lecommandoux, Sebastien ^{[1
]}

机构：

[1] Univ Bordeaux, IPB, ENSCBP, F-33607 Pessac, France

来源：

BIOMACROMOLECULES | 2013年 / 14卷 / 09期

关键词：

RING-OPENING POLYMERIZATION; SOLID-PHASE SYNTHESIS; CARRYING N-ACETYLLACTOSAMINE; BLOCK-COPOLYMERS; CHEMICAL-SYNTHESIS; TOXIN INHIBITION; FACILE SYNTHESIS; GLYCOPEPTIDE; SUGAR; GLYCOPOLYMERS;

D O I：

10.1021/bm4008088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycoproteins are naturally produced by protein glycosylation and are involved in a wide range of cellular functions. This Review aims to summarize the preparation of well-defined synthetic glycoproteins by using chemical routes as well as to highlight the preparation of ideal polymeric analogues of natural glycoproteins: glycopolypeptides. These macromolecules are simplified models of glycoproteins and are designed with the purpose of both mimicking the properties of natural glycoproteins as well as bringing innovative polymeric structures for materials science applications.

引用

收藏

页码：2973 / 2983

页数：11

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