Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles

被引：17

作者：

Liu, Feng ^{[1
]}

Wang, Meiyan ^{[2
]}

Teng, Xinhuan ^{[1
]}

Zhang, Peizhi ^{[2
]}

Jiang, Lin ^{[2
]}

机构：

[1] Shandong Agr Univ, Coll Plant Protect, Tai An 271018, Shandong, Peoples R China

[2] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2014年 / 40卷 / 04期

关键词：

1,3,4-Oxadiazole; Isoxazole; Synthesis; Antifungal activity; DERIVATIVES; ANALOGS;

D O I：

10.1007/s11164-013-1062-y

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A series of 2-(5-methyl-3-(4-chloro/trifluoromethylphenyl)isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles were synthesized from 4-chloro/trifluoromethyl benzaldehyde, ethyl acetoacetate, hydroxylamine hydrochloride, hydrazine hydrate, and aryl isocyanate by multi-step reactions. The structures of the target compounds were elucidated by IR, H-1 NMR, MS, and elemental analysis. All these compounds were tested for in vitro antifungal activities against Botrytis cinerea and Rhizoctonia cerealis by the mycelium growth rate method, and the results indicated that some compounds displayed high antifungal activity against Botrytis cinerea.

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收藏

页码：1575 / 1581

页数：7

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