PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

被引：2142

作者：

Mi, Huaiyu ^{[1
]}

Muruganujan, Anushya ^{[1
]}

Ebert, Dustin ^{[1
]}

Huang, Xiaosong ^{[1
,2
]}

Thomas, Paul D. ^{[1
]}

机构：

[1] Univ Southern Calif, Div Bioinformat, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA

[2] Guangzhou Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PROTEIN FAMILIES; GENE ONTOLOGY; EVOLUTION; DATABASE; PATHWAY;

D O I：

10.1093/nar/gky1038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

PANTHER (Protein Analysis Through Evolutionary Relationships, http://pantherdb.org) is a resource for the evolutionary and functional classification of genes from organisms across the tree of life. We report the improvements we have made to the resource during the past two years. For evolutionary classifications, we have added more prokaryotic and plant genomes to the phylogenetic gene trees, expanding the representation of gene evolution in these lineages. We have refined many protein family boundaries, and have aligned PANTHER with the MEROPS resource for protease and protease inhibitor families. For functional classifications, we have developed an entirely new PANTHER GO-slim, containing over four times as many Gene Ontology terms as our previous GO-slim, as well as curated associations of genes to these terms. Lastly, we have made substantial improvements to the enrichment analysis tools available on the PANTHER website: users can now analyze over 900 different genomes, using updated statistical tests with false discovery rate corrections for multiple testing. The overrepresentation test is also available as a web service, for easy addition to third-party sites.

引用

页码：D419 / D426

页数：8

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