A Self-Assembled Delivery Platform with Post-production Tunable Release Rate

被引：85

作者：

Boekhoven, Job ^{[1
]}

Koot, Mathijs ^{[1
]}

Wezendonk, Tim A. ^{[1
]}

Eelkema, Rienk ^{[1
]}

van Esch, Jan H. ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Chem Engn, NL-2628 BL Delft, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 31期

关键词：

DRUG-RELEASE; SENSITIVE LIPOSOMES; HYDROGELATORS; NANOSTRUCTURES; DOXORUBICIN; NANOFIBERS; MOLECULES; GELATOR; DESIGN;

D O I：

10.1021/ja3051876

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.

引用

收藏

页码：12908 / 12911

页数：4

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