Two tandem flow chemistry processes have been developed. A single palladium-catalysed Heck reaction with ethylene gas provides an efficient synthesis for functionalised styrenes. Through further elaboration the catalyst becomes multi-functional and performs a second Heck reaction providing a single continuous process for the synthesis of unsymmetrical stilbenes. In addition, the continuous, rhodium-catalysed, hydroformylation of styrene derivatives with syngas affords branched aldehydes with good selectivity. Incorporation of an in-line aqueous wash and liquid-liquid separation allowed for the ethylene Heck reaction to be telescoped into the hydroformylation step such that a single flow synthesis of branched aldehydes directly from aryl iodides was achieved. The tube-in-tube semi-permeable membrane-based gas reactor and liquid-liquid separator both play an essential role in enabling these telescoped flow processes.
机构:
Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Peyroux, E
Berthiol, F
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Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Berthiol, F
Doucet, H
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Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Doucet, H
Santelli, M
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Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
机构:
Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Peyroux, E
Berthiol, F
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Berthiol, F
Doucet, H
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France
Doucet, H
Santelli, M
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, FranceFac Sci & Tech St Jerome, CNRS, Lab Synth Organ Assoc, F-13397 Marseille, France