In situ reaction monitoring of microwave-mediated reactions using IR spectroscopy

被引:24
作者
Leadbeater, Nicholas E. [1 ]
机构
[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA
基金
美国国家科学基金会;
关键词
RAMAN-SPECTROSCOPY; DIGITAL CAMERA; TOOL; CHEMISTRY;
D O I
10.1039/c0cc01921f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An IR probe has been interfaced with a scientific microwave unit, this allowing for real-time in situ monitoring of microwave-assisted reactions using IR spectroscopy. A number of organic transformations have been probed and the apparatus shown to work effectively as a tool for qualitative studies.
引用
收藏
页码:6693 / 6695
页数:3
相关论文
共 24 条
[1]   The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674 [J].
Argentine, Mark D. ;
Braden, Timothy M. ;
Czarnik, Jeffrey ;
Conder, Edward W. ;
Dunlap, Steven E. ;
Fennell, Jared W. ;
LaPack, Mark A. ;
Rothhaar, Roger R. ;
Scherer, R. Brian ;
Schmid, Christopher R. ;
Vicenzi, Jeffrey T. ;
Wei, Jeffrey G. ;
Werner, John A. .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2009, 13 (02) :131-143
[2]   Real-time monitoring of microwave-promoted organometallic ligand-substitutionreactions using in situ Raman spectroscopy [J].
Barnard, Thomas M. ;
Leadbeater, Nicholas E. .
CHEMICAL COMMUNICATIONS, 2006, (34) :3615-3616
[3]   Watching microwave-promoted chemistry: reaction monitoring using a digital camera interfaced with a scientific microwave apparatus [J].
Bowman, Matthew D. ;
Leadbeater, Nicholas E. ;
Barnard, T. Michael .
TETRAHEDRON LETTERS, 2008, 49 (01) :195-198
[4]   Microwave enhanced synthesis [J].
Caddick, Stephen ;
Fitzmaurice, Richard .
TETRAHEDRON, 2009, 65 (17) :3325-3355
[5]   ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing [J].
Carter, Catherine F. ;
Lange, Heiko ;
Ley, Steven V. ;
Baxendale, Ian R. ;
Wittkamp, Brian ;
Goode, Jon G. ;
Gaunt, Nigel L. .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2010, 14 (02) :393-404
[6]   Probing of the microwave radiation effect on the green fluorescent protein luminescence in solution [J].
Copty, A ;
Sakran, F ;
Popov, O ;
Ziblat, R ;
Danieli, T ;
Golosovsky, M ;
Davidov, D .
SYNTHETIC METALS, 2005, 155 (02) :422-425
[7]   Chiral phosphoramide-catalyzed aldol additions of ketone trichlorosilyl enolates. Mechanistic aspects [J].
Denmark, SE ;
Pham, SM ;
Stavenger, RA ;
Su, XP ;
Wong, KT ;
Nishigaichi, Y .
JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (10) :3904-3922
[8]   Real time observation of microwave-enhanced reactions via fast FTIR spectroscopy [J].
Heller, Eberhard ;
Lautenschlaeger, Werner ;
Holzgrabe, Ulrike .
TETRAHEDRON LETTERS, 2009, 50 (12) :1321-1323
[9]   Remote analysis using IR glass fibers [J].
Hocdé, S ;
Boussard-Plédel, C ;
Le Coq, D ;
Fonteneau, G ;
Lucas, J .
INFRARED OPTICAL FIBERS AND THEIR APPLICATIONS, 1999, 3849 :50-59
[10]   Microwave dielectric heating in synthetic organic chemistry [J].
Kappe, C. Oliver .
CHEMICAL SOCIETY REVIEWS, 2008, 37 (06) :1127-1139