Green protocol for the Biginelli three-component reaction:: Ag3PW12O40 as a novel, water-tolerant heteropolyacid for the synthesis of 3,4-dihydropyrimidinones

被引：131

作者：

Yadav, JS ^{[1
]}

Reddy, BVS ^{[1
]}

Sridhar, P ^{[1
]}

Reddy, JSS ^{[1
]}

Nagaiah, K ^{[1
]}

Lingaiah, N ^{[1
]}

Saiprasad, PS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Catalysis Div, Hyderabad 500007, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 03期

关键词：

heteropolyacid; multicomponent reactions; polyoxometalates; water media;

D O I：

10.1002/ejoc.200300559

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Biginelli three-component condensation of an aldehyde, beta-keto ester, and urea proceeds smoothly on the surface of the silver salt of heteropolyacid (HPA), i.e. Ag3PW12O40, in water to afford the corresponding 3,4-dihydropyrimidinones in high-to-quantitative yields under mild conditions. The heterogeneous solid acid provides ease of separation of the catalyst and isolation of the products. The recovered catalyst can be recycled in subsequent reactions with consistent activity. Compared to the classical Biginelli reaction conditions, this new method has the advantages of improved yields, reusability of the catalyst, an eco-friendly solvent, ease of isolation of products, and simplicity in the experimental procedure. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

引用

页码：552 / 557

页数：6

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