Catalytic Acylation of Amines with Aldehydes or Aldoximes

被引：111

作者：

Allen, C. Liana ^{[1
]}

Davulcu, Simge ^{[1
]}

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

ONE-POT CONVERSION; ONE-STEP SYNTHESIS; OXIDATIVE AMIDATION; HIGHLY EFFICIENT; MILD AMIDATION; PRIMARY AMIDES; NITRILES; REARRANGEMENT; LANTHANIDE; COMPLEXES;

D O I：

10.1021/ol101978h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.

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收藏

页码：5096 / 5099

页数：4

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