Effects of some N-nitropyrazole derivatives on ocular blood flow and retinal function recovery after ischemic insult

被引：20

作者：

Xuan, B ^{[1
]}

Zhou, YH ^{[1
]}

Varma, R ^{[1
]}

Chiou, GCY ^{[1
]}

机构：

[1] Texas A&M Univ, Coll Med, Dept Med Pharmacol & Toxicol, College Stn, TX 77843 USA

来源：

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | 1999年 / 15卷 / 02期

关键词：

D O I：

10.1089/jop.1999.15.135

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Ocular blood flow and retinal function were determined in this study with colored microspheres and b-wave amplitude of electroretinography, respectively. It was found that N-nitropyrazole analogs can facilitate the retinal function recovery efficiently after ischemic insult primarily through increase of choroidal blood flow specifically. Since age-related macular degeneration (AMD) is caused mainly by the choroidal vascular abnormality and/or insufficiency, these N-nitropyrazole analogs are of potential use in the treatment of AMD.

引用

页码：135 / 142

页数：8

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