Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LGMS/MS) relevant to clinical and forensic toxicology

被引：141

作者：

Maurer, HH ^{[1
]}

机构：

[1] Univ Saarland, Dept Expt & Clin Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-66421 Homburg, Saar, Germany

来源：

CLINICAL BIOCHEMISTRY | 2005年 / 38卷 / 04期

关键词：

screening; quantification; drugs; liquid chromatography; mass spectrometry;

D O I：

10.1016/j.clinbiochem.2005.01.014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

This paper reviews multi-analyte procedures for screening and quantification :of drugs in blood, plasma, or serum using liquid chromatography Coupled with a single stage or tandem mass spectrometer (LC-MS, LC-MS/MS). These procedures are relevant tools in clinical and forensic toxicology, and cover analysis of aniphetarnines, cocaine, hallucinogens, opioids, anesthetics, hypnotics, benzodiazepines, antidepressants, neuroleptics, antihistamines, sulfonylurea-type antidiabetics, beta-blockers, and other cardiac drugs. Basic information on the procedures is given in two tables and multi-analyte screening, identification, and quantification are illustrated in three figures. A critical discussion on the pros and cons of such LC-MS procedures is also included. (c) 2005 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：310 / 318

页数：9

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