Surface-Engineered Polyelectrolyte Multilayer Capsules: Synthetic Vaccines Mimicking Microbial Structure and Function

被引：71

作者：

De Geest, Bruno G. ^{[1
]}

Willart, Monique A. ^{[2
]}

Lambrecht, Bart N. ^{[2
]}

Pollard, Charlotte ^{[3
,4
]}

Vervaet, Chris ^{[1
]}

Remon, Jean Paul ^{[1
]}

Grooten, Johan ^{[3
]}

De Koker, Stefaan ^{[3
]}

机构：

[1] Univ Ghent, Lab Pharmaceut Technol, Dept Pharmaceut, Ghent, Belgium

[2] Univ Ghent, Lab Mucosal Immunol & Immunoregulat, Ghent, Belgium

[3] Univ Ghent, Lab Mol Immunol, Dept Mol Biomed Biol, Ghent, Belgium

[4] Inst Trop Med, Dept Microbiol, Virol Unit, B-2000 Antwerp, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 16期

关键词：

antigens; drug delivery; immunology; polycations; self-assembly; DENDRITIC CELLS; ANTIGEN; DELIVERY; IMMUNITY; PROGRESS;

D O I：

10.1002/anie.201200048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells (see picture) and showed activity in further immunization experiments. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3862 / 3866

页数：5

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