Optoacoustic imaging based on the interferometric measurement of surface displacement

被引:48
作者
Carp, Stefan A. [1 ,2 ]
Venugopalan, Vasan [1 ,2 ]
机构
[1] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Laser Microbeam & Med Program, Beckman Laser Inst & Med Clin, Irvine, CA 92697 USA
基金
美国国家卫生研究院;
关键词
optoacoustic tomography; thermoelastic expansion; Mach-Zehnder interferometer; surface displacement;
D O I
10.1117/1.2812665
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present images of tissue phantoms and chicken chorio-allantoic membrane vasculature using a novel optoacoustic tomography technique based on the time-resolved interferometric measurement of laser-induced thermoelastic expansion. Our imaging system is based on a modified Mach-Zehnder interferometer that provides surface displacement measurements with a temporal resolution of 4 ns and a displacement sensitivity of 0.3 nm. The images are reconstructed from surface displacement measurements made at several locations following irradiation of the sample with Q-switched Nd:YAG (lambda= 532, 1064 nm) laser pulses using a delay and sum beam-forming algorithm. The images shown demonstrate the ability of our method to provide better than 200-mu m lateral and 30-mu m axial resolution at depths exceeding ten transport mean free paths in highly scattering in-vitro and in-vivo model systems. (C) 2007 Society of Photo-Optical Instrumentation Engineers.
引用
收藏
页数:9
相关论文
共 36 条
[1]   Optoacoustic imaging using thin polymer etalon [J].
Ashkenazi, S ;
Hou, Y ;
Buma, T ;
O'Donnell, M .
APPLIED PHYSICS LETTERS, 2005, 86 (13) :1-3
[2]   Two-dimensional ultrasound receive army using an angle-tuned Fabry-Perot polymer film sensor for transducer field characterization and transmission ultrasound imaging [J].
Beard, PC .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2005, 52 (06) :1002-1012
[3]   Three-dimensional volume rendering of spiral CT data: Theory and method [J].
Calhoun, PS ;
Kuszyk, BS ;
Heath, DG ;
Carley, JC ;
Fishman, EK .
RADIOGRAPHICS, 1999, 19 (03) :745-764
[4]   Optoacoustic imaging using interferometric measurement of surface displacement [J].
Carp, SA ;
Guerra, A ;
Duque, SQ ;
Venugopalan, V .
APPLIED PHYSICS LETTERS, 2004, 85 (23) :5772-5774
[5]  
Hecht E., 2017, Optics
[6]   Image reconstruction for photoacoustic scanning of tissue structures [J].
Hoelen, CGA ;
de Mul, FFM .
APPLIED OPTICS, 2000, 39 (31) :5872-5883
[7]   Three-dimensional photoacoustic imaging of blood vessels in tissue [J].
Hoelen, CGA ;
de Mul, FFM ;
Pongers, R ;
Dekker, A .
OPTICS LETTERS, 1998, 23 (08) :648-650
[8]   Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer [J].
Karabutov, AA ;
Savateeva, EV ;
Podymova, NB ;
Oraevsky, AA .
JOURNAL OF APPLIED PHYSICS, 2000, 87 (04) :2003-2014
[9]  
Karabutov AA, 2003, LASER PHYS, V13, P711
[10]  
Karabutov AA, 1996, APPL PHYS B-LASERS O, V63, P545