Facile syntheses of aryldifluorophosphonate building blocks

被引：20

作者：

Cockerill, GS

Easterfield, HJ

Percy, JM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Glaxo Wellcome, Med Res Ctr, Stevenage, Herts, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(99)00266-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F(2)Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-Miyaura couplings. Herein, we report a streamlined synthesis of F(2)Pmp, and of a pivotal triflate, which undergoes a range of palladium-catalysed couplings with aryl and heteroaryl components. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：2601 / 2604

页数：4

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