DNA Switches: From Principles to Applications

被引：398

作者：

Wang, Fuan ^{[1
]}

Liu, Xiaoqing ^{[1
]}

Willner, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 04期

关键词：

DNA machines; DNA switches; DNAzymes; electrochemistry; photochemistry; I-MOTIF DNA; MESOPOROUS SILICA NANOPARTICLES; INTERFACIAL ELECTRON-TRANSFER; DRIVEN CONFORMATIONAL SWITCH; G-QUADRUPLEX DNA; BASE-PAIRS; PH CHANGES; GOLD NANOPARTICLES; CONTROLLED-RELEASE; PLASMON RESONANCE;

D O I：

10.1002/anie.201404652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The base sequence of nucleic acid encodes structural and functional properties into the biopolymer. Structural information includes the formation of duplexes, G-quadruplexes, i-motif, and cooperatively stabilized assemblies. Functional information encoded in the base sequence involves the strand-displacement process, the recognition properties by aptamers, and the catalytic functions of DNAzymes. This Review addresses the implementation of the information encoded in nucleic acids to develop DNA switches. A DNA switch is a supramolecular nucleic acid assembly that undergoes cyclic, switchable, transitions between two distinct states in the presence of appropriate triggers and counter triggers, such as pHvalue, metal ions/ligands, photonic and electrical stimuli. Applications of switchable DNA systems to tailor switchable DNA hydrogels, for the controlled drug-release and for the activation of switchable enzyme cascades, are described, and future perspectives of the systems are addressed.

引用

页码：1098 / 1129

页数：32

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