LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

被引：185

作者：

Chen, Zhen-zhen ^{[1
]}

Huang, Lan ^{[2
]}

Wu, Ya-hong ^{[1
]}

Zhai, Wen-jie ^{[1
]}

Zhu, Ping-ping ^{[3
]}

Gao, Yan-feng ^{[1
,4
]}

机构：

[1] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[4] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan Province, Peoples R China

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

中国国家自然科学基金;

关键词：

CANCER STEM-CELLS; IDENTIFICATION; TRANSCRIPTION; ACTIVATION; BIOLOGY;

D O I：

10.1038/ncomms12598

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that LncSox4 is required for liver TIC self-renewal and tumour initiation. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver TICs and required for liver TIC self-renewal. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. Altogether, we find that LncSox4 is highly expressed in liver TICs and is required for their self-renewal.

引用

页数：13

共 38 条

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