C-H Bond Functionalization of Arylpyrimidines Catalyzed by an in situ Generated Ruthenium(II) Carboxylate System and the Construction of Tris(heteroaryl)-Substituted Benzenes

被引：39

作者：

Stefane, Bogdan ^{[1
,2
]}

Fabris, Jan ^{[1
,2
]}

Pozgan, Franc ^{[1
,2
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia

[2] EN FIST Ctr Excellence, Ljubljana 1000, Slovenia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 19期

关键词：

C-H activation; Arylation; Pyrimidine; Carboxylate ligands; Ruthenium; PROTON-ABSTRACTION MECHANISM; MEDIATED DIRECT ARYLATION; ARYL CHLORIDES; INTRAMOLECULAR ARYLATION; REGIOSELECTIVE ARYLATION; ACTIVATION; ARENES; ALKENYLATION; HETEROARENES; HALIDES;

D O I：

10.1002/ejoc.201100238

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium(II) carboxylate catalyst, generated in situ from [RuCl2(p-cymene)](2) and 1-phenyl-1-cyclopentanecarboxylic acid (PCCA) in the presence of K2CO3, allowed activation of the C-H bond in phenyl-substituted pyrimidines and their direct functionalization with both electron-deficient and electron-rich aryl halides. The scope of this process can be extended to the use of heteroaryl bromides and less reactive aryl chlorides. This Ru-II-PCCA complex constitutes a better catalytic system in comparison to other carboxylates.

引用

页码：3474 / 3481

页数：8

共 69 条

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