Diastereoselective alkylation of a newly designed bislactim ether towards the asymmetric synthesis of α-alkylated serines

被引:14
作者
Sano, S [1 ]
Takebayashi, M [1 ]
Miwa, T [1 ]
Ishii, T [1 ]
Nagao, Y [1 ]
机构
[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan
关键词
D O I
10.1016/S0957-4166(98)00370-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Diastereoselective alkylation of ethyl (5S)-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-pyrazinecarboxylate (5S)-3 with alkyl halides was investigated by using NaH and n-BuLi. These alkylated products (2R,5S)-4b-d were converted to the corresponding alpha-alkylated serines (S)-6b-d. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3611 / 3614
页数:4
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