Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing

被引：8

作者：

de la Rica, Roberto ^{[1
]}

Baldi, Antonio ^{[1
]}

Fernandez-Sanchez, Cesar ^{[1
]}

机构：

[1] Esfera UAB, CSIC, CNM, IMB, E-08193 Barcelona, Spain

来源：

APPLIED PHYSICS LETTERS | 2007年 / 90卷 / 07期

关键词：

D O I：

10.1063/1.2472718

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Chips containing polycrystalline silicon interdigitated electrodes are modified with the enzyme urease. The sensors are able to detect changes in the resitivity of the solution near their surface, where the enzymatic reaction generates charged species. The electrodes are also grafted with an antigen and queried with different amounts of urease labeled antibody. The response of the modified electrodes is proportional to the amount of enzyme attached to the surface by the biorecognition event, thus validating the assay for biosensing applications. (c) 2007 American Institute of Physics.

引用

页数：3

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