Catheter-based photoacoustic endoscope

被引:55
作者
Yang, Joon-Mo [1 ]
Li, Chiye [1 ]
Chen, Ruimin [2 ]
Zhou, Qifa [2 ]
Shung, K. Kirk [2 ]
Wang, Lihong V. [1 ]
机构
[1] Washington Univ, Dept Biomed Engn, Opt Imaging Lab, St Louis, MO 63130 USA
[2] Univ So Calif, NIH Ultrason Transducer Resource Ctr, Dept Biomed Engn, Los Angeles, CA 90089 USA
基金
美国国家卫生研究院;
关键词
photoacoustic endoscopy; flexible shaft; catheter endoscope; instrument channel; gastrointestinal endoscopy; rabbit esophagus; in vivo imaging; MICROSCOPY; TOMOGRAPHY; ULTRASOUND; BIOPSY;
D O I
10.1117/1.JBO.19.6.066001
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We report a flexible shaft-based mechanical scanning photoacoustic endoscopy (PAE) system that can be potentially used for imaging the human gastrointestinal tract via the instrument channel of a clinical video endoscope. The development of such a catheter endoscope has been an important challenge to realize the technique's benefits in clinical settings. We successfully implemented a prototype PAE system that has a 3.2-mm diameter and 2.5-m long catheter section. As the instrument's flexible shaft and scanning tip are fully encapsulated in a plastic catheter, it easily fits within the 3.7-mm diameter instrument channel of a clinical video endoscope. Here, we demonstrate the intra-instrument channel workability and in vivo animal imaging capability of the PAE system. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
引用
收藏
页数:12
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