Liquid chromatographic thermospray tandem mass spectrometric quantitative analysis of some drugs with hypnotic, sedative and tranquillising properties in whole blood

被引：36

作者：

Verweij, AMA

Hordijk, ML

Lipman, PJL

机构：

[1] Department of General Chemistry, Forensic Sci. Lab. of the Min. of J., 2288 GD Rijswijk

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1996年 / 686卷 / 01期

关键词：

benzodiazepines; thioxanthenes; butyrophenones; methadones; diphenylbutylpiperidines;

D O I：

10.1016/S0378-4347(96)00035-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Results are presented of a liquid chromatographic-thermospray tandem mass spectrometric method of analysing different drugs in whole blood. Substances with hypnotic, sedative and tranquillising properties from the benzodiazepine, the thioxanthene, the butyrophenone, the methadone and the diphenylbutylpiperidine groups were investigated. It appears that ten to hundred times lower detection limits for the substances in whole blood can be reached with this method compared with methods more commonly used. Detection limits in the range 10-100 pg per injection (equivalent to 0.05-0.5 ng/ml whole blood) were reached for the majority of the compounds.

引用

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页码：27 / 34

页数：8

相关论文

共 40 条

[31] SIMULTANEOUS DETERMINATION OF PROPOXYPHENE AND NORPROPOXYPHENE IN BIOLOGICAL SAMPLES BY GAS-CHROMATOGRAPHY USING AN ON-COLUMN INJECTION TECHNIQUE WITH A FUSED-SILICA CAPILLARY COLUMN [J].

SHIN, H ;

LHO, DS ;

PARK, JS .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 491 (02) :448-454

[32]

TAN ST, 1990, J CHROMATOGR-BIOMED, V532, P181

[33] SIMULTANEOUS DETERMINATION OF VERY LOW CONCENTRATIONS OF HALOPERIDOL AND REDUCED HALOPERIDOL IN HUMAN-SERUM BY A LIQUID-CHROMATOGRAPHIC METHOD [J].

VATASSERY, GT ;

HERZAN, LA ;

DYSKEN, MW .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 433 :312-317

[34] COMPARISON OF MASS-SPECTROMETRIC TECHNIQUES FOR THE ANALYSIS OF TRACE AMOUNTS OF 1-METHYLAMINOANTHRAQUINONE, USED AS SMOKE DYE IN EXPLODING MONEY SUITCASES [J].

VERWEIJ, AMA ;

LIPMAN, PJL .

JOURNAL OF CHROMATOGRAPHY A, 1993, 653 (02) :359-362

[35] QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRIC (LC/TSP/MS/MS) ANALYSIS OF SOME TRANQUILIZERS OF THE THIOXANTHENE GROUP IN WHOLE-BLOOD [J].

VERWEIJ, AMA ;

HORDIJK, ML ;

LIPMAN, PJL .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1994, 17 (19) :4099-4110

[36] QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRY (LC TSP MS MS) ANALYSIS OF SOME THERMOLABILE BENZODIAZEPINES IN WHOLE-BLOOD [J].

VERWEIJ, AMA ;

LIPMAN, PJL ;

ZWEIPFENNING, PGM .

FORENSIC SCIENCE INTERNATIONAL, 1992, 54 (01) :67-74

[37] QUANTITATIVE LIQUID-CHROMATOGRAPHIC THERMOSPRAY-TANDEM MASS-SPECTROMETRIC ANALYSIS OF SOME ANALGESICS AND TRANQUILIZERS OF THE METHADONE, BUTYROPHENONE OR DIPHENYLBUTYLPIPERIDINE GROUPS IN WHOLE-BLOOD [J].

VERWEIJ, AMA ;

HORDIJK, ML ;

LIPMAN, PJL .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1995, 19 (02) :65-68

[38] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR THE DETERMINATION OF CLOZAPINE, HALOPERIDOL, DROPERIDOL AND SEVERAL BENZODIAZEPINES IN PLASMA [J].

WILHELM, D ;

KEMPER, A .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (01) :218-224

[39]

YINON J, 1987, FORENSIC MASS SPECTR

[40]

ZECCA L, 1986, J CHROMATOGR, V377, P405

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