Steric Modulation of Chiral Biaryl Diamines via Pd-Catalyzed Directed C-H Arylation

被引：38

作者：

Scarborough, Christopher C. ^{[1
]}

McDonald, Richard I. ^{[1
]}

Hartmann, Caroline ^{[1
]}

Sazama, Graham T. ^{[1
]}

Bergant, Ana ^{[1
]}

Stahl, Shannon S. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 06期

关键词：

ANILIDE ORTHO-ARYLATION; SCHIFF-BASE COMPLEXES; DIELS-ALDER REACTION; ENANTIOSELECTIVE HYDROAMINATION/CYCLISATION; ASYMMETRIC CATALYSIS; ALKENE AZIRIDINATION; AMIDATE COMPLEXES; COPPER-COMPLEXES; LIGANDS; HYDROGENATION;

D O I：

10.1021/jo802632v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis.

引用

页码：2613 / 2615

页数：3

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