Antagonistic interactions between two MAP kinase cascades in plant development and immune signaling

被引：111

作者：

Sun, Tongjun ^{[1
]}

Nitta, Yukino ^{[1
]}

Zhang, Qian ^{[1
]}

Wu, Di ^{[1
]}

Tian, Hainan ^{[1
]}

Lee, Jin Suk ^{[2
]}

Zhang, Yuelin ^{[1
]}

机构：

[1] Univ British Columbia, Dept Bot, Vancouver, BC, Canada

[2] Concordia Univ, Dept Biol, Montreal, PQ, Canada

来源：

EMBO REPORTS | 2018年 / 19卷 / 07期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

MAPK signaling; MAPKKK3; MAPKKK5; PAMP-triggered immunity; YODA/YDA; ACTIVATED PROTEIN-KINASE; ARABIDOPSIS-THALIANA; STOMATAL DEVELOPMENT; MPK4; ACTIVATION; CELL-DEATH; MEKK1; PERCEPTION; PHOSPHORYLATION; BIOSYNTHESIS; RECEPTORS;

D O I：

10.15252/embr.201745324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitogen-activated protein kinase (MAPK) signaling plays important roles in diverse biological processes. In Arabidopsis, MPK3/MPK6, MKK4/MKK5, and the MAPKKK YODA (YDA) form a MAPK pathway that negatively regulates stomatal development. Brassinosteroid (BR) stimulates this pathway to inhibit stomata production. In addition, MPK3/MPK6 and MKK4/MKK5 also serve as critical signaling components in plant immunity. Here, we report that MAPKKK3/MAPKKK5 form a kinase cascade with MKK4/MKK5 and MPK3/MPK6 to transduce defense signals downstream of multiple plant receptor kinases. Loss of MAPKKK3/MAPKKK5 leads to reduced activation of MPK3/MPK6 in response to different pathogen-associated molecular patterns (PAMPs) and increased susceptibility to pathogens. Surprisingly, developmental defects caused by silencing of YDA are suppressed in the mapkkk3 mapkkk5 double mutant. On the other hand, loss of YDA or blocking BR signaling leads to increased PAMP-induced activation of MPK3/MPK6. These results reveal antagonistic interactions between a developmental MAPK pathway and an immune signaling MAPK pathway.

引用

页数：12

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