No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8

被引：86

作者：

Keaney, M ^{[1
]}

Gems, D ^{[1
]}

机构：

[1] UCL, Dept Biol, London WC1E 6BT, England

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2003年 / 34卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

enzyme mimetics; aging; antioxidant; superoxide dismutase; Caenorhabditis elegans; EUK-8; free radicals;

D O I：

10.1016/S0891-5849(02)01290-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide dismulase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions. (C) 2003 Elsevier Science Inc.

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收藏

页码：277 / 282

页数：6

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