Long non-coding RNAs and control of gene expression in the immune system

被引：225

作者：

Atianand, Maninjay K. ^{[1
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun,Div Infect Dis & Immunol, Worcester, MA 01655 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 11期

关键词：

long non-coding RNA; lncRNA; lincRNA; innate immunity; gene expression; epigenetics; GROWTH-ARREST; DENDRITIC CELLS; T-CELLS; TRANSCRIPTION; ANTISENSE; REVEALS; IDENTIFICATION; DIFFERENTIATION; ACTIVATION; ANNOTATION;

D O I：

10.1016/j.molmed.2014.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.

引用

页码：623 / 631

页数：9

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