Selective palladium-catalyzed amination of the heterocyclic core of variolins

被引：14

作者：

Baeza, Alejandro ^{[1
]}

Burgos, Carolina ^{[1
]}

Alvarez-Builla, Julio ^{[1
]}

Vaquero, Juan J. ^{[1
]}

机构：

[1] Univ Alcala de Henares, Dept Quim Organ, Madrid, Spain

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 14期

关键词：

pyrido[3 ',3 ': 4,5]pyrrolo[1,2-c]pyrimidine; N-tosylmethyl dichloroformimide; amination; palladium-catalyzed; variolins; SPONGE KIRKPATRICKIA-VARIALOSA; TOSYLMETHYL ISOCYANIDE; ALKALOIDS VARIOLINS; ARYL HALIDES; MERIDIANINS; DERIVATIVES; ARYLAMINES; OXAZOLES; SYSTEM;

D O I：

10.1016/j.tetlet.2007.02.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and selective palladium-catalyzed amination of the pyrido[3',3':4,5]pyrrolo[1,2-c]pyrimidine nucleus, the heterocyclic core of the variolin alkaloids, is described. The method allows the introduction of amino and aryl- and alkyjamino substituents on the C9 position in advanced precursors of variolin B and deoxyvariolin. (c) 2007 Published by Elsevier Ltd.

引用

页码：2597 / 2601

页数：5

共 31 条

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