Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction

被引：24

作者：

Jida, Mouhamad

Malaquin, Sandra

Deprez-Poulain, Rebecca ^{[1
]}

Laconde, Guillaume

Deprez, Benoit

机构：

[1] Univ Lille Nord France, Fac Pharm, INSERM U761, F-59006 Lille, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 39期

关键词：

4-Center 3-component Ugi; Ketoacids; Microwave; Solvent-free; Lactams; MULTICOMPONENT REACTIONS; AMINO-ACIDS; CONDENSATION; EFFICIENT; PART;

D O I：

10.1016/j.tetlet.2010.07.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five- and six-membered lactams were synthesized via a 4-center 3-component Ugi reaction by combining amines, isocyanides, and ketoacids under solvent-free microwave conditions. The reaction was carried out in much shorter times and the yields were improved in comparison to classical conditions. (c) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：5109 / 5111

页数：3

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