STRUCTURE-ACTIVITY STUDIES ON PSEUDO-SYMMETRICAL HIV-1 PROTEASE INHIBITORS

被引：8

作者：

BABINE, RE

ZHANG, N

SCHOW, SR

JIROUSEK, MR

JOHNSON, BD

KERWAR, SS

DESAI, PR

BYRN, RA

HASTINGS, RC

WICK, MM

机构：

[1] Exploratory Medicinal Chemistry Section American Cyanamid Co. Medical Research Div. Lederle Labs. Pe

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80023-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lead compound 1, obtained from a previously reported structure-assisted design approach, was optimized to 17 using a traditional medicinal chemistry approach.

引用

页码：1589 / 1594

页数：6

共 21 条

[1] HIGHLY DIASTEREOSELECTIVE ALKYLATIONS OF CHIRAL AMIDE ENOLATES - NEW ROUTES TO HYDROXYETHYLENE DIPEPTIDE ISOSTERE INHIBITORS OF HIV-1 PROTEASE [J].

ASKIN, D ;

WALLACE, MA ;

VACCA, JP ;

REAMER, RA ;

VOLANTE, RP ;

SHINKAI, I .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (10) :2771-2773

[2] THE USE OF HIV-1 PROTEASE STRUCTURE IN INHIBITOR DESIGN [J].

BABINE, RE ;

ZHANG, N ;

JURGENS, AR ;

SCHOW, SR ;

DESAI, PR ;

JAMES, JC ;

SEMMELHACK, MF .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (06) :541-546

[3]

BABINE RE, UNPUB

[4]

CASTRO B, 1975, TETRAHEDRON LETT, P1219

[5] DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS - VARIATIONS OF THE CARBOXY TERMINUS OF THE HIV PROTEASE INHIBITOR-L-682,679 [J].

DESOLMS, SJ ;

GIULIANI, EA ;

GUARE, JP ;

VACCA, JP ;

SANDERS, WM ;

GRAHAM, SL ;

WIGGINS, JM ;

DARKE, PL ;

SIGAL, IS ;

ZUGAY, JA ;

EMINI, EA ;

SCHLEIF, WA ;

QUINTERO, JC ;

ANDERSON, PS ;

HUFF, JR .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) :2852-2857

[6] DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].

ERICKSON, J ;

NEIDHART, DJ ;

VANDRIE, J ;

KEMPF, DJ ;

WANG, XC ;

NORBECK, DW ;

PLATTNER, JJ ;

RITTENHOUSE, JW ;

TURON, M ;

WIDEBURG, N ;

KOHLBRENNER, WE ;

SIMMER, R ;

HELFRICH, R ;

PAUL, DA ;

KNIGGE, M .

SCIENCE, 1990, 249 (4968) :527-533

[7] ASYMMETRIC ALKYLATION REACTIONS OF CHIRAL IMIDE ENOLATES - A PRACTICAL APPROACH TO THE ENANTIOSELECTIVE SYNTHESIS OF ALPHA-SUBSTITUTED CARBOXYLIC-ACID DERIVATIVES [J].

EVANS, DA ;

ENNIS, MD ;

MATHRE, DJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (06) :1737-1739

[8] HIV PROTEASE - A NOVEL CHEMOTHERAPEUTIC TARGET FOR AIDS [J].

HUFF, JR .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2305-2314

[9] PENICILLIN DERIVED C2-SYMMETRICAL DIMERS AS NOVEL INHIBITORS OF HIV-1 PROTEINASE [J].

HUMBER, DC ;

CAMMACK, N ;

COATES, JAV ;

COBLEY, KN ;

ORR, DC ;

STORER, R ;

WEINGARTEN, GG ;

WEIR, MP .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (16) :3080-3081

[10] SYNTHESIS OF C2-SYMMETRICAL HIV-1 PROTEASE INHIBITORS FROM D-MANNITOL [J].

JADHAV, PK ;

WOERNER, FJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (04) :353-356

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