Kumada-Tamao-Corriu Coupling of Alkyl Halides Catalyzed by an Iron-Bisphosphine Complex

被引：83

作者：

Hatakeyama, Takuji ^{[1
]}

Fujiwara, Yu-ichi ^{[1
,2
]}

Okada, Yoshihiro ^{[1
,2
]}

Itoh, Takuma ^{[1
,2
]}

Hashimoto, Toru ^{[1
,2
]}

Kawamura, Shintaro ^{[1
,2
]}

Ogata, Kazuki ^{[1
,2
]}

Takaya, Hikaru ^{[1
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, IRCELS, ICR, Kyoto 6110011, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158530, Japan

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 09期

基金：

日本学术振兴会;

关键词：

ARYL GRIGNARD-REAGENTS; BOND FORMATION; PHOSPHATES; SUBSTITUTION; REACTIVITY; COBALT; SALTS;

D O I：

10.1246/cl.2011.1030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iron(II) chloride complex possessing a sterically demanding ortho-phenylene-tethered bisphosphine ligand shows a high catalytic activity in the Kumada-Tamao-Corriu coupling of nonactivated alkyl halides with aryl Grignard reagents. Primary, secondary, and tertiary alkyl halides can participate as an electrophilic coupling partner. A radical clock experiment using (iodomethyl)cyclopropane exclusively gives the corresponding ring-opening coupling product, suggesting intermediacy of alkyl radical species.

引用

页码：1030 / 1032

页数：3

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