Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

被引：44

作者：

Cardo, Lucia ^{[1
]}

Sadovnikova, Victoria ^{[1
]}

Phongtongpasuk, Siriporn ^{[1
]}

Hodges, Nikolas J. ^{[2
]}

Hannon, Michael J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期

关键词：

METALLOSUPRAMOLECULAR CYLINDERS; TRIPLE HELICATE; RECOGNITION; RESOLUTION; PEPTIDES; DESIGN;

D O I：

10.1039/c1cc11356a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

引用

页码：6575 / 6577

页数：3

共 31 条

[1] An enantiomerically pure dinuclear triple-stranded helicate:: X-ray structure, CD spectroscopy and DFT calculations [J].

Albrecht, M ;

Janser, I ;

Fleischhauer, J ;

Wang, YK ;

Raabe, G ;

Fröhlich, R .

MENDELEEV COMMUNICATIONS, 2004, 14 (06) :250-253

[2] Anticancer activity of opened arene ruthenium metalla-assemblies [J].

Barry, Nicolas P. E. ;

Zava, Olivier ;

Furrer, Julien ;

Dyson, Paul J. ;

Therrien, Bruno .

DALTON TRANSACTIONS, 2010, 39 (22) :5272-5277

[3] Regio- and diastereo-selective formation of dicopper(I) and disilver(I) double helicates with chiral 6-substituted 2,2′:6′,2"-terpyridines [J].

Baum, G ;

Constable, EC ;

Fenske, D ;

Housecroft, CE ;

Kulke, T ;

Neuburger, M ;

Zehnder, M .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2000, (06) :945-959

[4] Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides [J].

Cardo, Lucia ;

Hannon, Michael J. .

INORGANICA CHIMICA ACTA, 2009, 362 (03) :784-792

[5] Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides [J].

Cosgrave, Lynda ;

Devocelle, Marc ;

Forster, Robert J. ;

Keyes, Tia E. .

CHEMICAL COMMUNICATIONS, 2010, 46 (01) :103-105

[6] Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro [J].

Ducani, Cosimo ;

Leczkowska, Anna ;

Hodges, Nikolas J. ;

Hannon, Michael J. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (47) :8942-8945

[7] Membrane-permeable arginine-rich peptides and the translocation mechanisms [J].

Futaki, S .

ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (04) :547-558

[8] Design and non-covalent DNA binding of platinum(II) metallacalix[4]arenes [J].

Galindo, Miguel A. ;

Olea, David ;

Angustias Romero, M. ;

Gomez, Julio ;

del Castillo, Pedro ;

Hannon, Michael J. ;

Rodger, Alison ;

Zamora, Felix ;

Navarro, Jorge A. R. .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (18) :5075-5081

[9] Microwave Synthesis of a Rare [Ru2L3]4+ Triple Helicate and Its Interaction with DNA [J].

Glasson, Christopher R. K. ;

Meehan, George V. ;

Clegg, Jack K. ;

Lindoy, Leonard F. ;

Smith, Jayden A. ;

Keene, F. Richard ;

Motti, Cherie .

CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (34) :10535-10538

[10] Directed one-pot syntheses of enantiopure dinuclear silver(I) and copper(I) metallo-supramolecular double helicates [J].

Hamblin, J ;

Childs, LJ ;

Alcock, NW ;

Hannon, MJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2002, (02) :164-169

← 1 2 3 4 →