Synthesis of topostins B567 and D654 (WB-3559D, flavolipin), DNA topoisomerase I inhibitors of bacterial origin

被引：16

作者：

Shioiri, T ^{[1
]}

Terao, Y ^{[1
]}

Irako, N ^{[1
]}

Aoyama, T ^{[1
]}

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 51期

关键词：

topostin; enzyme inhibitors; asymmetric reaction; coupling;

D O I：

10.1016/S0040-4020(98)00984-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Topostins B567 (2b) and D654 (3b) (WB-3559D, flavolipin) have been efficiently synthesized from 1,10-decanediol (5) in 11 and 13 steps, respectively, involving an asymmetric hydrogenation of the beta-keto ester 14 using (R)-BINAP ruthenium bromide and a peptide coupling using diethyl phosphorocyanidate (DEPC, (EtO)(2)P(O)CN) as key steps. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：15701 / 15710

页数：10

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