A novel Cu-catalysed three-component one-pot synthesis of dihydro-pyrimidin-2(1H)-ones using microwaves under solvent-free conditions

被引：182

作者：

Gohain, M

Prajapati, D ^{[1
]}

Sandhu, JS

机构：

[1] Reg Res Lab, Div Med Chem, Jorhat 785006, Assam, India

[2] Punjabi Univ, Dept Chem, Patiala 147002, Punjab, India

来源：

SYNLETT | 2004年 / 02期

关键词：

biginelli condensation; cupric chloride; cupric sulphate; dihydropyrimidinones; three-component reactions;

D O I：

10.1055/s-2003-43374

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cupric chloride dihydrate catalyzes the three-component Biginelli condensation between an aldehyde, a beta-ketoester and urea or thiourea under microwave irradiation in the absence of solvent to yield various substituted 3,4-dihydropyrimidin-2(1H)-ones. The reaction is also effective when performed at room temperature in acetonitrile or at 100 degreesC in a solvent free approach, without any side reactions as observed by Biginelli and others.

引用

收藏

页码：235 / 238

页数：4

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