Acetogenins from Annonaceae:: recent progress in isolation, synthesis and mechanisms of action

被引:526
作者
Bermejo, A
Figadère, B
Zafra-Polo, MC
Barrachina, I
Estornell, E
Cortes, D
机构
[1] Univ Paris Sud, Fac Pharm, CNRS BIOCIS, Lab Pharmacognosie, F-92296 Chatenay Malabry, France
[2] Univ Valencia, Fac Farm, Dept Farmacol, E-46100 Valencia, Spain
[3] Univ Valencia, Fac Farm, Dept Bioquim & Biol Mol, E-46100 Valencia, Spain
关键词
D O I
10.1039/b500186m
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such interesting natural products. In fact, of the 417 isolated compounds reviewed, over 176 have been added during the period from 1998 to 2004.
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页码:269 / 303
页数:35
相关论文
共 177 条
[21]   Novel cytotoxic annonaceous acetogenins from Annona muricata [J].
Chang, FR ;
Wu, YC .
JOURNAL OF NATURAL PRODUCTS, 2001, 64 (07) :925-931
[22]   Purpuracenin:: a new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Annona purpurea [J].
Chávez, D ;
Mata, R .
PHYTOCHEMISTRY, 1999, 50 (05) :823-828
[23]   Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea [J].
Chávez, D ;
Mata, R .
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (05) :580-584
[24]   Jimenezin, a novel annonaceous acetogenin from the seeds of Rollinia mucosa containing adjacent tetrahydrofuran-tetrahydropyran ring systems [J].
Chávez, D ;
Acevedo, LA ;
Mata, R .
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04) :419-421
[25]   Aromin-A, an Annonaceous acetogenin from Annona cherimola [J].
Chen, CY ;
Chang, FR ;
Chiu, HF ;
Wu, MJ ;
Wu, YC .
PHYTOCHEMISTRY, 1999, 51 (03) :429-433
[26]  
Chen WS, 1997, ACTA CHIM SINICA, V55, P723
[27]  
CHEN WS, 1995, ACTA CHIM SINICA, V53, P516
[28]   Two linear acetogenins from Goniothalamus gardneri [J].
Chen, Y ;
Jiang, Z ;
Chen, RR ;
Yu, DQ .
PHYTOCHEMISTRY, 1998, 49 (05) :1317-1321
[29]   A new epimeric pair of mono-THF Annonaceous acetogenins from Goniothalamus gardneri [J].
Chen, Y ;
Chen, RR ;
Jiang, Z ;
Yu, DQ .
PLANTA MEDICA, 1998, 64 (03) :242-245
[30]   Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells [J].
Chiu, HF ;
Chih, TT ;
Hsian, YM ;
Tseng, CH ;
Wu, MJ ;
Wu, YC .
BIOCHEMICAL PHARMACOLOGY, 2003, 65 (03) :319-327