Hematopoietic stem cells and their niche

被引：169

作者：

Suda, T ^{[1
]}

Arai, F ^{[1
]}

Hirao, A ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat,Shinjuku Ku, Tokyo 1608582, Japan

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.it.2005.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.

引用

收藏

页码：426 / 433

页数：8

相关论文

共 63 条

[41] Stemness: Transcriptional profiling of embryonic and adult stem cells [J].

Ramalho-Santos, M ;

Yoon, S ;

Matsuzaki, Y ;

Mulligan, RC ;

Melton, DA .

SCIENCE, 2002, 298 (5593) :597-600

[42] Stem cells, cancer, and cancer stem cells [J].

Reya, T ;

Morrison, SJ ;

Clarke, MF ;

Weissman, IL .

NATURE, 2001, 414 (6859) :105-111

[43] Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification [J].

Ruggero, D ;

Grisendi, S ;

Piazza, F ;

Rego, E ;

Mari, F ;

Rao, PH ;

Cordon-Cardo, C ;

Pandolfi, PP .

SCIENCE, 2003, 299 (5604) :259-262

[44] Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells [J].

Samper, E ;

Fernández, P ;

Eguía, R ;

Martín-Rivera, L ;

Bernad, A ;

Blasco, MA ;

Aracil, M .

BLOOD, 2002, 99 (08) :2767-2775

[45]

SCHOFIELD R, 1978, BLOOD CELLS, V4, P7

[46] Role of Akt signaling in vascular homeostasis and angitogenesis [J].

Shiojima, I ;

Walsh, K .

CIRCULATION RESEARCH, 2002, 90 (12) :1243-1250

[47] Identification of human brain tumour initiating cells [J].

Singh, SK ;

Hawkins, C ;

Clarke, ID ;

Squire, JA ;

Bayani, J ;

Hide, T ;

Henkelman, RM ;

Cusimano, MD ;

Dirks, PB .

NATURE, 2004, 432 (7015) :396-401

[48] Germline, stem cells anchored by adherens junctions in the Drosophila ovary niches [J].

Song, XQ ;

Zhu, CH ;

Doan, C ;

Xie, T .

SCIENCE, 2002, 296 (5574) :1855-1857

[49] PURIFICATION AND CHARACTERIZATION OF MOUSE HEMATOPOIETIC STEM-CELLS [J].

SPANGRUDE, GJ ;

HEIMFELD, S ;

WEISSMAN, IL .

SCIENCE, 1988, 241 (4861) :58-62

[50] Stem cells find their niche [J].

Spradling, A ;

Drummond-Barbosa, D ;

Kai, T .

NATURE, 2001, 414 (6859) :98-104

← 1 2 3 4 5 6 7 →