Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy

被引:883
作者
Kim, Jaeyun
Piao, Yuanzhe
Hyeon, Taeghwan [1 ]
机构
[1] Seoul Natl Univ, Natl Creat Res Initiat Ctr Oxide Nanocrystalline, Seoul 151744, South Korea
关键词
NEAR-INFRARED AGENTS; MRI CONTRAST AGENTS; MAGNETIC-RESONANCE; SILICA NANOPARTICLES; IN-VIVO; DRUG-DELIVERY; QUANTUM DOTS; PHOTODYNAMIC THERAPY; BIOMEDICAL APPLICATIONS; HYBRID NANOPARTICLES;
D O I
10.1039/b709883a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanotechnology offers tremendous potential for future biomedical technology. Due to their unique characteristics including superparamagnetic or fluorescent properties, and small size comparable to biomolecules, nanostructured materials have emerged as novel bioimaging, diagnostic, and therapeutic agents for the future medical field. Especially, the combinations of various nanostructured materials with different properties can offer synergetic multifunctional nanomedical platforms, which make it possible to accomplish multimodal imaging, and simultaneous diagnosis and therapy. Moreover, the conjugation of targeting moieties on the surface of these multifunctional nanomaterials gives them specific targeted imaging and therapeutic properties. In this tutorial review, we will summarize the recent reports on the fabrication strategies of multifunctional nanoplatforms and their applications to targeted multimodal imaging and simultaneous diagnosis and therapy.
引用
收藏
页码:372 / 390
页数:19
相关论文
共 61 条
[51]   FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents [J].
Seo, Won Seok ;
Lee, Jin Hyung ;
Sun, Xiaoming ;
Suzuki, Yoriyasu ;
Mann, David ;
Liu, Zhuang ;
Terashima, Masahiro ;
Yang, Philip C. ;
McConnell, Michael V. ;
Nishimura, Dwight G. ;
Dai, Hongjie .
NATURE MATERIALS, 2006, 5 (12) :971-976
[52]   Gold nanocages for biomedical applications [J].
Skrabalak, Sara E. ;
Chen, Jingyi ;
Au, Leslie ;
Lu, Xianmao ;
Li, Xingde ;
Xia, Younan .
ADVANCED MATERIALS, 2007, 19 (20) :3177-3184
[53]   Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging [J].
Talanov, Vladimir S. ;
Regino, Celeste A. S. ;
Kobayashi, Hisataka ;
Bernardo, Marcelino ;
Choyke, Peter L. ;
Brechbiel, Martin W. .
NANO LETTERS, 2006, 6 (07) :1459-1463
[54]   Mesoporous silica nanospheres as highly efficient MRI contrast agents [J].
Taylor, Kathryn M. L. ;
Kim, Jason S. ;
Rieter, William J. ;
An, Hongyu ;
Lin, Weili ;
Lin, Wenbin .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (07) :2154-+
[55]   High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe [J].
Tsai, Chih-Pin ;
Hung, Yann ;
Chou, Yi-Hsin ;
Huang, Dong-Ming ;
Hsiao, Jong-Kai ;
Chang, Chen ;
Chen, Yao-Chang ;
Mou, Chung-Yuan .
SMALL, 2008, 4 (02) :186-191
[56]   Optical and MRI multifunctional nanoprobe for targeting gliomas [J].
Veiseh, O ;
Sun, C ;
Gunn, J ;
Kohler, N ;
Gabikian, P ;
Lee, D ;
Bhattarai, N ;
Ellenbogen, R ;
Sze, R ;
Hallahan, A ;
Olson, J ;
Zhang, MQ .
NANO LETTERS, 2005, 5 (06) :1003-1008
[57]   Cell-specific targeting of nanoparticles by multivalent attachment of small molecules [J].
Weissleder, R ;
Kelly, K ;
Sun, EY ;
Shtatland, T ;
Josephson, L .
NATURE BIOTECHNOLOGY, 2005, 23 (11) :1418-1423
[58]   Au-Fe3O4 dumbbell nanoparticles as dual-functional probes [J].
Xu, Chenjie ;
Xie, Jin ;
Ho, Don ;
Wang, Chao ;
Kohler, Nathan ;
Walsh, Edward G. ;
Morgan, Jeffrey R. ;
Chin, Y. Eugene ;
Sun, Shouheng .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (01) :173-176
[59]   GdIII-functionalized fluorescent quantum dots as multimodal imaging probes [J].
Yang, Heesun ;
Santra, Swadeshmukul ;
Walter, Glenn A. ;
Holloway, Paul H. .
ADVANCED MATERIALS, 2006, 18 (21) :2890-+
[60]   Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer [J].
Yang, Jaemoon ;
Lee, Choong-Hwan ;
Ko, Hyun-Ju ;
Suh, Jin-Suck ;
Yoon, Ho-Geun ;
Lee, Kwangyeol ;
Huh, Yong-Min ;
Haam, Seungjoo .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (46) :8836-8839