Dynamic regulation of transcriptional states by chromatin and transcription factors

被引：345

作者：

Voss, Ty C. ^{[1
]}

Hager, Gordon L. ^{[1
]}

机构：

[1] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 02期

关键词：

ESTROGEN-RECEPTOR-ALPHA; EUKARYOTIC GENE-EXPRESSION; SINGLE-MOLECULE TRACKING; GLUCOCORTICOID-RECEPTOR; LIVING CELLS; DNA-BINDING; IN-VIVO; EPIGENETIC SIGNATURES; BIOLOGICAL-SYSTEMS; PROTEIN DYNAMICS;

D O I：

10.1038/nrg3623

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.

引用

页码：69 / 81

页数：13

共 124 条

[1] Network motifs: theory and experimental approaches [J].

Alon, Uri .

NATURE REVIEWS GENETICS, 2007, 8 (06) :450-461

[2] DIFFERENTIAL STEROID-HORMONE INDUCTION OF TRANSCRIPTION FROM THE MOUSE MAMMARY-TUMOR VIRUS PROMOTER [J].

ARCHER, TK ;

LEE, HL ;

CORDINGLEY, MG ;

MYMRYK, JS ;

FRAGOSO, G ;

BERARD, DS ;

HAGER, GL .

MOLECULAR ENDOCRINOLOGY, 1994, 8 (05) :568-576

[3] Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription [J].

Ashall, Louise ;

Horton, Caroline A. ;

Nelson, David E. ;

Paszek, Pawel ;

Harper, Claire V. ;

Sillitoe, Kate ;

Ryan, Sheila ;

Spiller, David G. ;

Unitt, John F. ;

Broomhead, David S. ;

Kell, Douglas B. ;

Rand, David A. ;

See, Violaine ;

White, Michael R. H. .

SCIENCE, 2009, 324 (5924) :242-246

[4] A decade of exploring the cancer epigenome - biological and translational implications [J].

Baylin, Stephen B. ;

Jones, Peter A. .

NATURE REVIEWS CANCER, 2011, 11 (10) :726-734

[5] Dynamic behavior of transcription factors on a natural promoter in living cells [J].

Becker, M ;

Baumann, C ;

John, S ;

Walker, DA ;

Vigneron, M ;

McNally, JG ;

Hager, GL .

EMBO REPORTS, 2002, 3 (12) :1188-1194

[6] GENOMIC FOOTPRINTING REVEALS CELL TYPE SPECIFIC DNA-BINDING OF UBIQUITOUS FACTORS [J].

BECKER, PB ;

RUPPERT, S ;

SCHUTZ, G .

CELL, 1987, 51 (03) :435-443

[7] Activation of Estrogen Receptor-α by E2 or EGF Induces Temporally Distinct Patterns of Large-Scale Chromatin Modification and mRNA Transcription [J].

Berno, Valeria ;

Amazit, Larbi ;

Hinojos, Cruz ;

Zhong, Jeannie ;

Mancini, Maureen G. ;

Sharp, Zelton Dave ;

Mancini, Michael A. .

PLOS ONE, 2008, 3 (05)

[8] Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding [J].

Biddie, Simon C. ;

John, Sam ;

Sabo, Pete J. ;

Thurman, Robert E. ;

Johnson, Thomas A. ;

Schiltz, R. Louis ;

Miranda, Tina B. ;

Sung, Myong-Hee ;

Trump, Saskia ;

Lightman, Stafford L. ;

Vinson, Charles ;

Stamatoyannopoulos, John A. ;

Hager, Gordon L. .

MOLECULAR CELL, 2011, 43 (01) :145-155

[9] Noise in eukaryotic gene expression [J].

Blake, WJ ;

Kærn, M ;

Cantor, CR ;

Collins, JJ .

NATURE, 2003, 422 (6932) :633-637

[10] Removal of promoter nucleosomes by disassembly rather than sliding in vivo [J].

Boeger, H ;

Griesenbeck, J ;

Strattan, JS ;

Kornberg, RD .

MOLECULAR CELL, 2004, 14 (05) :667-673

← 1 2 3 4 5 6 7 8 9 10 →