Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H2-D2O system

被引：73

作者：

Esaki, Hiroyoshi ^{[1
]}

Aoki, Fumiyo ^{[1
]}

Umemura, Miho ^{[1
]}

Kato, Masatsugu ^{[1
]}

Maegawa, Tomohiro ^{[1
]}

Monguchi, Yasunari ^{[1
]}

Sajiki, Hironao ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 14期

关键词：

C-H activation; deuterium; heterogeneous catalysis; isotopic labeling; palladium;

D O I：

10.1002/chem.200601615

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D2O as a deuterium source under hydrogen atmosphere is described. Multideuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C-H-2-D2O system. ne present method does not require expensive deuterium gas or any special equipment.

引用

页码：4052 / 4063

页数：12

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