SYNTHESIS OF 3'-FUNCTIONALIZED OLIGONUCLEOTIDES ON A SINGLE SOLID SUPPORT

被引：14

作者：

HOVINEN, J ^{[1
]}

GUZAEV, A ^{[1
]}

AZHAYEV, A ^{[1
]}

LONNBERG, H ^{[1
]}

机构：

[1] UNIV TURKU,DEPT CHEM,SF-20500 TURKU,FINLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)61482-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligodeoxyribonucleotides tethered with an amino-, carboxy-, amidocarbonyl-, or mercaptoalkyl spacer arm at 3'-terminus were obtained by assembling the chains on a modified aminoalkyl-CPG (1) and releasing them with appropriate reagents.

引用

页码：8169 / 8172

页数：4

共 23 条

[1] SOLID-PHASE PREPARATION OF 5', 3'-HETEROBIFUNCTIONAL OLIGODEOXYRIBONUCLEOTIDES USING MODIFIED SOLID SUPPORTS
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[2] NEW SOLID-PHASE FOR AUTOMATED SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING AN AMINO-ALKYL LINKER AT THEIR 3'-END
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[3] ATKINSON T, 1984, OLIGONUCLEOTIDE SYNT, P47
[4] SOLID-PHASE SYNTHESIS OF 5',3'-BIFUNCTIONAL OLIGODEOXYRIBONUCLEOTIDES BEARING A MASKED THIOL-GROUP AT THE 3'-END
BONFILS, E
THUONG, NT
[J]. TETRAHEDRON LETTERS, 1991, 32 (26) : 3053 - 3056
[5] GAMBER HB, 1993, NUCLEIC ACIDS RES, V21, P145
[6] SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A CARBOXYL GROUP AT EITHER THEIR 5' END OR THEIR 3' END AND THEIR SUBSEQUENT DERIVATIZATION BY AN INTERCALATING AGENT
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[J]. TETRAHEDRON LETTERS, 1990, 31 (46) : 6657 - 6660
[7] PHOTOCHEMICAL CLEAVAGE OF OLIGONUCLEOTIDES FROM SOLID-PHASE SUPPORTS
GREENBERG, MM
[J]. TETRAHEDRON LETTERS, 1993, 34 (02) : 251 - 254
[8] ANCHOR FOR ONE-STEP RELEASE OF 3'-AMINOOLIGONUCLEOTIDES FROM A SOLID SUPPORT
GRYAZNOV, SM
LETSINGER, RL
[J]. TETRAHEDRON LETTERS, 1993, 34 (08) : 1261 - 1264
[9] A GENERAL-METHOD FOR THE SYNTHESIS OF 3'-SULFHYDRYL AND PHOSPHATE GROUP CONTAINING OLIGONUCLEOTIDES
GUPTA, KC
SHARMA, P
KUMAR, P
SATHYANARAYANA, S
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (11) : 3019 - 3025
[10] A UNIVERSAL SOLID SUPPORT FOR THE SYNTHESIS OF 3'-THIOL GROUP CONTAINING OLIGONUCLEOTIDES
GUPTA, KC
SHARMA, P
SATHYANARAYANA, S
KUMAR, P
[J]. TETRAHEDRON LETTERS, 1990, 31 (17) : 2471 - 2474

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