The integration of flow reactors into synthetic organic chemistry

被引：222

作者：

Baxendale, Ian R. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2013年 / 88卷 / 04期

关键词：

review; flow chemistry; organic synthesis; heterocycles; automation; technology; POLYMER-SUPPORTED REAGENTS; AMARYLLIDACEAE ALKALOID (+)-PLICAMINE; ENABLING TECHNOLOGY; MULTISTEP SYNTHESIS; IMMOBILIZED REAGENTS; MICROFLUIDIC DEVICES; MICROWAVE CHEMISTRY; PROCESS WINDOWS; SCAVENGERS; BATCH;

D O I：

10.1002/jctb.4012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The material presented in this review is based upon discussions and interactions with members of the Department of Chemistry and Biochemistry within the University of Windsor, Ontario, Canada. This article explores the changing face of chemical synthesis with regard to the impact of flow based chemical processing technologies. Highlighted works from the Innovative Technology Centre (ITC), Cambridge, UK, are used to illustrate the alternative synthetic practices available to modern research chemists. The dominant theme of the review is the synergistic effects encountered by combining the advantages of continuous processing regimes with the power of immobilized reagents and scavenger systems for multi-step organic chemistry. (c) 2012 Society of Chemical Industry

引用

页码：519 / 552

页数：34

共 162 条

[121] Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor
Schmink, Jason R.
Kormos, Chad M.
Devine, William G.
Leadbeater, Nicholas E.
[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2010, 14 (01) : 205 - 214
[122] Pd-EnCat™ TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions
Sedelmeier, Joerg
Ley, Steven V.
Lange, Heiko
Baxendale, Ian R.
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (26) : 4412 - 4420
[123] E factors, green chemistry and catalysis: an odyssey
Sheldon, Roger A.
[J]. CHEMICAL COMMUNICATIONS, 2008, (29) : 3352 - 3365
[124] Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines
Smith, Catherine J.
Iglesias-Sigueenza, Francisco Javier
Baxendale, Ian R.
Ley, Steven V.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (17) : 2758 - 2761
[125] Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
Smith, Catherine J.
Smith, Christopher D.
Nikbin, Nikzad
Ley, Steven V.
Baxendale, Ian R.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (06) : 1927 - 1937
[126] A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Smith, Catherine J.
Nikbin, Nikzad
Ley, Steven V.
Lange, Heiko
Baxendale, Ian R.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (06) : 1938 - 1947
[127] [3+2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
Smith, Christopher D.
Baxendale, Ian R.
Lanners, Steve
Hayward, John J.
Smith, Stephen C.
Ley, Steven V.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (10) : 1559 - 1561
[128] Solid-supported reagents and catch-and-release techniques in organic synthesis
Solinas, Antonio
Taddei, Maurizio
[J]. SYNTHESIS-STUTTGART, 2007, 16 (16): : 2409 - 2453
[129] Real-Time Product Switching Using a Twin Catalyst System for the Hydrogenation of Furfural in Supercritical CO2
Stevens, James G.
Bourne, Richard A.
Twigg, Martyn V.
Poliakoff, Martyn
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (47) : 8856 - 8859
[130] Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C
Storer, RI
Takemoto, T
Jackson, PS
Brown, DS
Baxendale, IR
Ley, SV
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (10) : 2529 - 2547

← 8 9 10 11 12 13 14 15 16 17 →