Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

被引:171
作者
Ackermann, Lutz [1 ]
Wang, Lianhui [1 ]
Lygin, Alexander V. [1 ]
机构
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
关键词
C BOND FORMATION; INDOLE SYNTHESES; DIRECT ARYLATION; H ACTIVATION; FUNCTIONALIZATION; ALKALOIDS; CLEAVAGE; LAMELLARINS; ALKENE; AIR;
D O I
10.1039/c1sc00619c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)(2)center dot H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloids.
引用
收藏
页码:177 / 180
页数:4
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